Physician’s Profile

Emmanouil Pappou, MD, PhD

NewYork-Presbyterian/Lawrence Hospital
Board Certificates: 
Colon and Rectal Surgery
Colon & Rectal Cancer
Laparoscopic Colon and Rectal Surgery
Robotic Surgery
Colorectal Cancer
Sphincter Saving Operations
Pelvic Floor Disorders
Fecal Incontinence
Ostomy Creation, Care and Revision
Inflammatory Bowel Diseases (IBD)
Rectal Prolapse
Anal Fissure and Fistula
2012 The Chesapeake Colorectal Society Lee E. Smith Spring Scientific Meeting Award
2011 Recognition of service as Vice-President of House Staff Council at the Johns Hopkins Hospital
2011 Second Best Grant Proposal at the AACR Workshop on Molecular Biology in Clinical Oncology
2010 Johns Hopkins George D. Zuidema Research Award for Meritorious Laboratory Research
2009 Johns Hopkins Department of Surgery Core Values in Practice Award
2005 “Cornell – Austauschprogramm” scholarship from the Technical University of Munich in Germany

Dr. Pappou completed his General Surgery residency training at the Johns Hopkins Hospital in 2014, with a Research Fellowship in Surgical Oncology at the Sidney Kimmel Comprehensive Cancer Center (Johns Hopkins). He has completed a Clinical Fellowship in Colon and Rectal Surgery at NewYork-Presbyterian/Weill Cornell and the Memorial Sloan Kettering Cancer Center in 2015.

His clinical interests include the entire spectrum of colorectal surgery including benign and malignant conditions, anorectal, abdominal and pelvic surgery as well as minimally invasive techniques including laparoscopic, robotic and endoluminal procedures. Dr. Pappou is well versed in utilizing minimally invasive approaches including robotic surgery and sacral neurostimulation (SNS). Dr. Pappou is the surgical lead of the pelvic floor center within the division of colorectal surgery, working with gastroenterologists, urologists and gynecologists to develop a one-stop program for evaluation and treatment of problems related to colon transit, constipation, pelvic floor and evacuatory dysfunction as well as fecal incontinence.

His position also includes leadership in clinical and laboratory research and outcomes within the division of colorectal surgery. He has a keen interest in research and is an author on numerous publications in peer-reviewed journals, published abstracts, oral presentations and book chapters.

Dr. Pappou has been the recipient of numerous prestigious awards, including the Johns Hopkins George D. Zuidema Research Award for Meritorious Laboratory Research for work on novel chemotherapy treatments in colorectal cancer.

A native of Greece, Dr. Pappou graduated from the Medical School of the Technical University of Munich with honors in 2006 and completed a Ph.D. on human stem cells at the research laboratory of the Ludwig Maximilian University of Munich, Germany.

Pappou EP, Weiser M. Robotic colectomy. Journal of Surgical Oncology (invited review, accepted January 2015.
Tao Fu, E.P.Pappou, Angela A. Guzzetta, Marilia de Freitas Calmon, Lifeng Sun, Alexander Herrera, Stephen B. Baylin, Christopher L. Wolfgang, Christine A. Iacobuzio-Donahue, Weidong Tong, and Nita Ahuja, IGFBP3 gene methylation predicts recurrence of stage II colorectal cancers. Annals Of Surgery (submitted), 2014.
Marilia Freitas Calmon, J.J., Wei Zhang, Mashaal Dhir, Cornelia Siebenks, Alexander Herrera, Hsing-Chen Tsai, Heather M. O’Hagan, Emmanouil P. Pappou, Craig M. Hooker, Tao Fu, Kornel E. Schuebel, Edward Gabrielson, Paula Rahal, James G. Herman, Stephen B. Baylin and Nita Ahuja, Epigenetic Silencing of Neurofilament Genes Promotes an Aggressive Phenotype in Breast Cancer Cells. Breast Cancer Research (submitted), 2014.
Juo, Y.Y., F. Johnston, D. Zhang, H.H. Juo, H. Wang, E.P. Pappou, T. Yu, H. Easwaran, S. Baylin, M. Engeland, and N. Ahuja, Prognostic Value of CpG Island Methylator Phenotype among Colorectal Cancer Patients: A Systematic Review and Meta-Analysis. Ann Oncol, 2014.
Jesse Qualliotine, E.P.Pappou, Daniela Molena, and Young Kim, Case of the Month: Persistent Cough in Nonsmoking Woman. ENTtoday, March 2014.
Hicks, C.W., E.P. Pappou, J.T. Magruder, B. Gazer, S. Fang, E.C. Wick, S.L. Gearhart, N. Ahuja, and J.E. Efron, Clinicopathologic Presentation and Natural History of Anorectal Melanoma: A Case Series of 18 Patients. JAMA Surg, 2014.
Emmanouil Pappou, T.Reifsnyder, A classic article that has never been read in English. Journal of Vascular Surgery (accepted), 2014.
Emmanouil P. Pappou, J.T.Magruder, Caitlin W. Hicks, Joseph M. Herman, Eric B. Schneider Sandy Fang, Elizabeth C. Wick, Bashar Safar, Susan L. Gearhart, and Jonathan E. Efron, Prognostic and predictive clinicopathologic factors of anal canal cancer in HIV-positive and HIV-negative patients: Does HAART therapy influence outcomes?`. Gastrointest Cancer Res (accepted), 2014.
Yi, J.M., A.A. Guzzetta, V.J. Bailey, S.R. Downing, L. Van Neste, K.B. Chiappinelli, B.P. Keeley, A. Stark, A. Herrera, C. Wolfgang, E.P. Pappou, C.A. Iacobuzio-Donahue, M.G. Goggins, J.G. Herman, T.H. Wang, S.B. Baylin, and N. Ahuja, Novel methylation biomarker panel for the early detection of pancreatic cancer. Clin Cancer Res, 2013. 19(23): p. 6544-55.
Tsai, H.C., H. Li, L. Van Neste, Y. Cai, C. Robert, F.V. Rassool, J.J. Shin, K.M. Harbom, R. Beaty, E. Pappou, J. Harris, R.W. Yen, N. Ahuja, M.V. Brock, V. Stearns, D. Feller-Kopman, L.B. Yarmus, Y.C. Lin, A.L. Welm, J.P. Issa, I. Minn, W. Matsui, Y.Y. Jang, S.J. Sharkis, S.B. Baylin, and C.A. Zahnow, Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell, 2012. 21(3): p. 430-46.
Pappou, E.P., C. Velopulos, E.K. Fishman, and E.R. Haut, Image of the month. Hernia containing omentum and right gastroepiploic artery. Arch Surg, 2012. 147(11): p. 1065-6.
Fu, T., E.P. Pappou, A.A. Guzzetta, J. Jeschke, R. Kwak, P. Dave, C.M. Hooker, R. Morgan, S.B. Baylin, C.A. Iacobuzio-Donahue, C.L. Wolfgang, and N. Ahuja, CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis. Clin Cancer Res, 2012. 18(17): p. 4743-52.
Poultsides, G.A., E.P. Pappou, G.P. Bloom, and R. Orlando, 3rd, Hybrid resection of duodenal tumors. J Laparoendosc Adv Surg Tech A, 2011. 21(7): p. 603-8.
Dhir, M., S. Yachida, L. Van Neste, S.C. Glockner, J. Jeschke, E.P. Pappou, E.A. Montgomery, J.G. Herman, S.B. Baylin, C. Iacobuzio-Donahue, and N. Ahuja, Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. Int J Cancer, 2011. 129(8): p. 1889-98.
Pappou, E.P. and N. Ahuja, The role of oncogenes in gastrointestinal cancer. Gastrointest Cancer Res, 2010(Suppl 1): p. S2-s15.
Pappou E, Eckhauser.F., Commentary: Treatment guidelines and quality of care for patients with squamous carcinoma of the anal canal. The American Journal of Hematology/Oncology, 2009. 8(4): p. 185-186.
Bocker, W., D. Docheva, W.C. Prall, V. Egea, E. Pappou, O. Rossmann, C. Popov, W. Mutschler, C. Ries, and M. Schieker, IKK-2 is required for TNF-alpha-induced invasion and proliferation of human mesenchymal stem cells. J Mol Med (Berl), 2008. 86(10): p. 1183-92.
J. Wolf, E. Pappou, C. Hicks, T. Magruder, L. Schwartz, S. Fang, E. Wick, B. Safar, S. Gearhart, J. Efron, Gastrointestinal stromal tumors in the rectum and anus: A retrospective single-institution analysis.,in American Society of Colon and Rectal Surgeons (ASCRS) 2014: Hollywood, FL. Poster 201.
A. Guzzetta, C.M.H., K. Ibrahim, E. Pappou, P. Dave, C. Wolfgang, T. Pawlik, E. A. Montgomery, Patients with Recurrent Retroperitoneal Sarcomas Benefit from Agressive Surgical Resections, in SSO Annual Cancer Symposium 2013: National Harbor, MD.
C. Hicks, E.Pappou, B. Gazer, J. Magruder, S. Fang, E. Wick, S. Gearhart, J. Efron, Clinicopathologic presentation and natural history of anorectal melanoma: A case series of 13 patients, in American Society of Colon and Rectal Surgeons (ASCRS) 2013: Phoenix, AZ. p. P174.
T. Magruder, E.Pappou, J. Bennett, F. Monn, E. Hechenbleikner, J. Herman, S. Gearhart, E. Wick, J. Efron, Analysis of clinicopathologic predictors of recurrence and survival in anal canal cancer, in American Society of Colon and Rectal Surgeons (ASCRS) 2012: San Antonio, Tx. p. Poster 119.
Emmanouil Pappou, J.M.Yi, James Shin, Leander van Neste, Alexander Herrera, Jana Jeschke, Cynthia Zahnow, S. B. Baylin, N. Ahuja, Role of epigenetic therapy in colorectal cancer: Effects of 5-azacytidine treatment in murine xenograft models., in 5th Annual Department of Surgery Research Poster Session 2011: Baltimore, MD.
Emmanouil Pappou, J.M.Yi, Mashaal Dhir, Jana Jeschke, S. B. Baylin, and N. Ahuja, Methylation of the FOXE1 and SYNE1 genes is frequently detected in colorectal adenomas and cancers in 4th Annual Department of Surgery Research Poster Session 2010: Baltimore, MD.
Emmanouil Pappou, J.Y., Alex Herrera, James Shin, Jana Jeschke, Cynthia Zahnow, Stephen Baylin, Nita Ahuja, Role of Epigenetic Therapy in Colorectal Cancer: Effects of 5-Azacytidine Treatment in Murine Xenograft Models, in American College of Surgeons, 96th Annual Clinical Congress 2010: Washington, DC.
Hsing-Chen Tsai, L.V.N., Huili Li, Yi Cai, Carine Robert, James J. Shin, Emmanouil Pappou, Ray-Whay Yen, IL Minn, Nita Ahuja, Malcolm V. Brock, Feyruz V. Rassool, Yoon-Young Jang, Saul J. Sharkis, William Matsui, Cynthia A. Zahnow, Stephen B. Baylin, Transient exposure to low-dose decitabine and azacytidine reprograms cancer cells to produce a prolonged antitumor response, in Proceedings of the 101st Annual Meeting of the American Association for Cancer Research 2010.
Wolfgang Bocker, E.Pappou, Virginia Egea-Alonso, V.K.-K. Denitsa Docheva, Christian Ries, and W.M. Oliver Rossmann, Matthias Schieker, NF-KB plays a critical role in human mesenchymal stem cell invasion in vitro, in 9th Annual Meeting on Surgical Research / 9. Chirurgische Forschungstage 2005: Frankfurt am Main, Germany.
E. P. Pappou, S.L.Gearhart, Anal Cancer, in Clinical Decision Support System on Surgery, LLC. Decision Support in Medicine. 2014.
Emmanouil P. Pappou, A.A.G., Nita Ahuja, Taking Action-Comprehensive Treatment Considerations, in Johns Hopkins Patient Guide To Colon And Rectal Cancer, N. Ahuja, Editor 2013, Jones & Bartlett Learning.
Pappou, E.P., "Body as a Whole" Section Editor, in The Johns Hopkins ABSITE Review Manual, M.R. Van Arendok KJ, Lipsett PA, Editor 2013, Lippincott Williams & Wilkins
Emmanouil Pappou, K.S., When patients have rib fractures, always assume associated solid organ injuries and treat pain aggressively, in Avoiding Common Errors in the Emergency Department, C. Mattu, Swadron, Tibbles, Woolridge, Editor 2010, Lippincott Williams & Wilkins.
Stephanie R. Downing, Emmanouil P.Pappou, Nita Ahuja, Behavior and Dietary Modification in the Prevention of Colon Cancer, in Early Diagnosis and Treatment of Cancer Series: Colorectal Cancer, N.A. Susan Gearhart, Editor 2010, Saunders.